Lung cancer in never-smokers (LCINS) ranks as the seventh most common cause of cancer-related death worldwide. The National Lung Screening Trial (NLST) showed screening for lung cancer using low-dose computed tomography (LDCT) reduced lung cancer mortality rate for 20% in high-risk individuals in the United States. The mortality reduction success…
Mutations in lamin A (LMNA) are responsible for a variety of human dystrophic and metabolic diseases.Dr. Ya‐Hui Chi from the Institute of Biotechnology and Pharmaceutical Research has previously reported the accumulation of progerin, the lamin A mutant protein that causes Hutchinson–Gilford progeria syndrome (HGPS) and an inner nuclear membrane protein…
The use of nanomaterials in industrial and consumer applications has resulted in a rapid increase in the numbers of workers exposed to engineered nanoparticles. Although no human illness to date is confirmed to be attributed to engineered nanoparticles, occupational epidemiological studies are needed to verify the health effects of nanoparticles.…
Cholinergic neurotransmission regulates the immune response and inhibits cytokine release after stroke. Post-stroke plasma acetylcholinesterase (AChE) and butylcholinesterase (BChE) are two major enzymes regulating the plasma level of Ach, which binds a muscarinic receptor on macrophages to regulate the inflammatory response after stroke. To date, the changes in the level/activity…
Macrophages form a major cell population in the tumor microenvironment. They can be activated and polarized into tumor-associated macrophages (TAM) by the tumor-derived soluble molecules to promote tumor progression and metastasis. Dr. Cheng-Chin Kuo and his team from the Institute of Cellular and System Medicine used comparative metabolomics coupled with…
Cardiovascular diseases remain the leading cause of morbidity and mortality worldwide, particularly among older adults. Despite the advent of medical technology, restenosis is still an issue after interventional procedures. Tryptophan metabolite 5-methoxytryptophan (5-MTP) has recently been shown to protect against systemic inflammatory responses. Dr. Shaw-Fang Yet from the Institute of…
December 9, 2019 Scientists with Taiwan’s National Health Research Institutes (NHRI) and National Taiwan University Hospital, with the support of the Taiwan Cooperative Oncology Group (TCOG), have determined that prophylactic antiviral therapy for lymphoma patients will be essential to optimizing preventative strategies and the allocation of medical resources. In hepatitis…
Frequent drinking associated with risk of head and neck cancer: NHRI study November 25, 2019 Higher frequency and amount of alcohol use are associated with an increased head and neck cancer risk, according to the results of a study conducted by the National Health Research Institutes’ National Institute of…
November 18, 2019 A free new smartphone application, Rhythm, developed by Dr. Yu-Hsuan Lin of the National Research Health Institutes, is a breakthrough for measuring sleep patterns that can help people improve their sleep health and consequently their overall quality of life. Its features represent an important advance over what…
November 11, 2019 Dysregulation of androgen receptor signaling is one of the causes promoting the development of prostate cancer, benign prostate hyperplasia (BPH), and androgenetic alopecia. The prescription drugs for these diseases either block the production of androgen or inhibit the binding between androgen and androgen receptor (AR). However,…
